Short inversions and conserved gene cluster
نویسندگان
چکیده
منابع مشابه
Simultaneous Identification of Conserved Regions and Inversions through Global Optimization
We propose a new method for the comparative analysis of two long DNA sequences. Our method is the first that takes into account biological events like local inversions when searching for highly conserved regions. Our method introduces new ideas to the usual concept of alignments, that detects events like insertions, deletions and mutations but not inversions. It proposes a weighted bipartite-ma...
متن کاملDetection and validation of single gene inversions
MOTIVATION The biologically meaningful algorithmic study of genome rearrangement should take into account the distribution of sizes of the rearranged genomic fragments. In particular, it is important to know the prevalence of short inversions in order to understand the patterns of gene order disruption observed in comparative genomics. RESULTS We find a large excess of short inversions, espec...
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Chromosomal rearrangements occur readily in nature and are a major reshaping force during genome evolution. Such large scale modifications are usually deleterious causing several fitness defects, but sometimes can confer an advantage and become adaptive. For example the DAL metabolic cluster in yeast was assembled in recent evolutionary times in the Hemiascomycetes lineage, through a set of rea...
متن کاملCLUSTER ALGEBRAS AND CLUSTER CATEGORIES
These are notes from introductory survey lectures given at the Institute for Studies in Theoretical Physics and Mathematics (IPM), Teheran, in 2008 and 2010. We present the definition and the fundamental properties of Fomin-Zelevinsky’s cluster algebras. Then, we introduce quiver representations and show how they can be used to construct cluster variables, which are the canonical generator...
متن کاملDNA inversions between short inverted repeats in Escherichia coli.
Using site-specific mutagenesis in vitro, we have constructed Escherichia coli strains that allow the detection of the inversion of an 800-bp segment in the lac region. The invertible segment is bounded by inverted repeats of either 12 or 23 bp. Inversions occurring at these inverted repeats will restore the Lac+ phenotype. Inversions can be detected at both short homologies at frequencies rang...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2002
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/18.10.1305